Genetic Obesity News

February 25, 2021February 25, 2021

VDR Gene Variations Increase Obesity Risk in Type 2 Diabetes, Study Finds

Certain variations in the DNA sequence of the vitamin D receptor (VDR) gene increase the risk for obesity in patients with type 2 diabetes, a South Korean study reports. The ... Read more

February 22, 2021February 22, 2021

Case Highlights Unusual Respiratory Features in Severe Bardet-Biedl Syndrome

Genetic Obesity News

A case study of a baby with Bardet-Biedl syndrome (BBS) highlights the unusual respiratory features that result from inheriting two mutant copies of the BBS10 gene. The report, “Bardet-Biedl syndrome ... Read more

February 19, 2021February 19, 2021

Eurordis Survey: Healthcare Experience Worse for Rare Disease Patients

Genetic Obesity News

People with rare disorders have a worse healthcare experience than those affected by chronic diseases, according to the results of an international survey conducted by Eurordis-Rare Diseases Europe. Indeed, rare ... Read more

February 18, 2021February 18, 2021

Gene Active in Skeletal Muscle Controls Mice’s Fat Metabolism

Genetic Obesity News

Skeletal muscle regulates how the body stores and metabolizes fats through the Krüppel-like factor 15 (KLF15) gene, establishing a molecular link between muscle health and conditions such as obesity and ... Read more

February 15, 2021February 16, 2021

Polynesian Ancestry Linked to Obesity in Study of Native Hawaiians

Genetic Obesity News

Native Hawaiians of Polynesian ancestry are at an increased risk of obesity, heart failure, and type 2 diabetes, a study has found. The greater risk of diabetes is linked to ... Read more

February 11, 2021February 11, 2021

Problems With MRP4 Gene Raises Obesity Risk, Mouse Study Suggests

Genetic Obesity News

Suppressing the activity of a cellular transporter called multidrug resistance protein 4 (Mrp4) results in more fat tissue, less energy expenditure, and insulin resistance, according to a study in mice. ... Read more

February 10, 2021February 10, 2021

Pandemic Won’t Stop Rare Disease Day on Feb. 28

COVID-19 News, Genetic Obesity News

Scores of virtual events are afoot around the world to mark Rare Disease Day 2021 on Feb. 28. The activities are focused on heightening awareness about rare diseases and the ... Read more

February 8, 2021February 8, 2021

Volunteers Sought for Large Home-based Study on Diabetes, Obesity

Genetic Obesity News

Scripps Research and Tempus are launching a study that uses genetic and other information to better understand what drives the development of obesity and type 2 diabetes. By understanding how ... Read more

February 4, 2021February 4, 2021

Genetics, Mental Health May Be Risk Factors for Teen Eating Disorders

Genetic Obesity News

Genetic predisposition, mental health symptoms, personality traits, substance abuse, and high body mass index (BMI) all are early risk factors for eating disorders in adolescence, a study has determined. These findings ... Read more

February 3, 2021February 3, 2021

NORD’s 6th ‘State Report Card’ Notes Progress, Raises Concerns

Genetic Obesity News

While progress was made last year on newborn screening and other policy issues critical to rare disease patients, a “State Report Card” argues that many concerns — notably out-of-pocket costs ... Read more

February 1, 2021February 2, 2021

Rhythm Seeks to Test Setmelanotide in More Obesity Disorders This Year

Genetic Obesity News

Rhythm Pharmaceuticals has identified 31 additional genes whose mutations may be amenable to setmelanotide, its U.S.-approved therapy for genetic obesity disorders linked to the melanocortin-4 receptor (MC4R) pathway. This discovery is ... Read more

January 28, 2021January 29, 2021

FDA-approved Setmelanotide Shows Promise in More Genetic Obesity Disorders

Genetic Obesity News

Three months of treatment with setmelanotide, an approved therapy for genetic obesity disorders, led to clinically meaningful body weight loss in adolescents and adults with additional diseases linked to the ... Read more

January 25, 2021January 25, 2021

Low Genetic Risk Helps to Protect Against Obesity, Decades-long Study Finds

Genetic Obesity News

A large-scale study spanning six decades found that people in Norway who are least genetically predisposed to obesity are relatively protected from it, while those most predisposed are at risk of ... Read more

January 21, 2021January 21, 2021

Mediterranean Diet May Counteract Genetic Risk for Teen Obesity

Genetic Obesity News

The Mediterranean diet reduces obesity-related metrics in adolescents, but it is not as effective in males who have a high genetic risk for obesity, a study has found. In female ... Read more

January 18, 2021January 18, 2021

Trim28 Gene Implicated in Fat Storage, Obesity, Mouse Study Reports

Genetic Obesity News

Deleting a gene called Trim28 in mice led to alterations in fat storage and metabolism, especially in female mice, who became significantly heavier, a study reported. These findings demonstrate Trim28‘s ... Read more