Cushing’s Disease News

June 17, 2022June 17, 2022

New Data Support Long-term Efficacy, Safety of Isturisa

Treatment with Isturisa (osilodrostat) normalized urine cortisol levels up to nearly 1.5 years in people with Cushing’s disease, according to data from the Phase 3 LINC-4 clinical trial. Data from ... Read more

June 15, 2022June 15, 2022

Transsphenoidal Surgery May Be Safe for Older Adults, Study Shows

Cushing's Disease News

Transsphenoidal surgery (TSS), a minimally invasive surgery to remove tumors from the brain’s pituitary gland, was deemed safe and effective to treat Cushing’s disease in a 67-year-old woman, as described ... Read more

June 10, 2022June 10, 2022

Bilateral Adrenalectomy Riskier Than Unilateral, Study Says

Cushing's Disease News

A bilateral adrenalectomy — a surgery to remove both adrenal glands — to lower cortisol levels in patients with Cushing’s syndrome was associated with more severe post-surgery complications and a ... Read more

June 8, 2022June 8, 2022

Abdominal Obesity May Be Due to Tissue Response to High Cortisol

Cushing's Disease News

The levels of an enzyme that activates glucocorticoids, including cortisol, from their inactive forms, are increased in abdominal fat tissue — abdominal obesity is a hallmark of Cushing’s syndrome — ... Read more

June 3, 2022June 3, 2022

Cushing’s Linked to Structural, Functional Changes in Brain’s Hippocampus

Cushing's Disease News

People with Cushing’s disease have structural and functional changes in the hippocampus — a brain region involved in memory, emotions, and stress responses — relative to healthy individuals, a small ... Read more

June 1, 2022June 1, 2022

Urinary Cortisol Not Ideal Cushing’s Biomarker, Analysis Suggests

Cushing's Disease News

Lowering excess cortisol within cells using SPI-62, an investigational treatment of Cushing’s-related conditions, did not affect urinary cortisol levels, a standard measure of therapy effectiveness in clinical trials, an analysis ... Read more

May 27, 2022May 27, 2022

CRN04894 Lowers Blood Cortisol Levels, Top-line Trial Data Show

Cushing's Disease News

CRN04894, a first-in-class, experimental oral medication for Cushing’s disease, led to a dose-dependent drop in blood and urine cortisol levels in healthy volunteers, top-line data from a Phase 1 trial ... Read more

May 25, 2022May 25, 2022

Woman’s Blurry Vision Leads to Rare Cushing’s Syndrome Diagnosis

Cushing's Disease News

The case of a woman with a rare form of Cushing’s syndrome whose main symptom was blurry vision was described in a recent report. The report, “Intermittent Blurry Vision: An ... Read more

May 20, 2022May 20, 2022

Long-term Isturisa Lessens Cushing’s Physical Features, Trial Data Show

Cushing's Disease News

Nearly 1.5 years of treatment with Isturisa (osilodrostat) rapidly and sustainably eased — and in many cases completely eliminated — disease-associated physical features in people with Cushing’s disease, according to ... Read more

May 18, 2022May 18, 2022

Recorlev Helps to Keep Cholesterol in Check, LOGICS Trial Data Show

Cushing's Disease News

Continuous treatment with Recorlev (levoketoconazole) helped to lower blood cholesterol levels in adults with endogenous Cushing’s syndrome, according to data from the Phase 3 LOGICS trial. Scientists at Xeris Biopharma, the ... Read more

May 13, 2022May 13, 2022

Pituitary Tumors in Cushing’s Have More Genetic Abnormalities: Study

Cushing's Disease News

Pituitary tumors producing excessive amounts of adrenocorticotropic hormone (ACTH) — the most common cause of Cushing’s disease — carry more genetic abnormalities than those not generating excess ACTH levels, also ... Read more

May 11, 2022May 11, 2022

High Copeptin Levels After Surgery May Be Linked to Remission

Cushing's Disease News

High levels of the hormone precursor copeptin following surgery might be associated with remission in people with Cushing’s disease who do not later develop water balance disorders, new data indicate. ... Read more

May 6, 2022May 6, 2022

Managing Co-existing Diseases May Improve Survival in Cushing’s

Cushing's Disease News

People with Cushing’s syndrome, a group of conditions that includes Cushing’s disease, have a three-times-higher risk of mortality compared with the general population, according to a pooled analysis of multiple ... Read more

May 5, 2022May 5, 2022

Organizations Rally to Help Ukrainian Rare Disease Patients

Cushing's Disease News

A Russian military plane crash near Tetiana Zamorska’s home in Kyiv, Ukraine, was a sign that it was time for her and her family to leave. The treacherous, 34-hour pilgrimage that ... Read more

May 4, 2022May 4, 2022

Does Size Really Matter? Maybe Not for Cushing’s Pituitary Tumors

Cushing's Disease News

The size of pituitary tumors that cause Cushing’s disease do not affect the levels of cortisol or clinical features in patients, a study suggests. The tumor’s ability to invade other ... Read more