Angioedema News

October 23, 2020October 23, 2020

Telehealth ‘Helpful’ Alternative to In-person Care, Rare Disease Patients Say

A majority of rare disease patients using telehealth during the COVID-19 pandemic thought the experience positive, and many would like the option of continuing its use in future appointments, a series ... Read more

October 19, 2020October 19, 2020

KalVista Plans Phase 2 Trial for KVD824, Will Develop Factor XIIa Preventive Treatment

Angioedema News

KalVista Pharmaceuticals is planning to initiate a Phase 2 trial of its investigational oral therapy KVD824 as a preventive treatment for hereditary angioedema (HAE) attacks, the company announced. The decision ... Read more

October 16, 2020October 16, 2020

Intellia’s NTLA-2002 Reduces Kallikrein Protein Levels for 11 Months in Preclinical Study

Angioedema News

A single dose of NTLA-2002, Intellia Therapeutics’ investigational gene-editing therapy for hereditary angioedema (HAE), induces sustained reductions in the activity of plasma kallikrein — a protein involved in HAE swelling ... Read more

October 12, 2020October 12, 2020

Fresh Frozen Plasma May Work to Treat HAE Swelling Attacks in Poorer Countries, Case Finds

Angioedema News

In cases where targeted treatment for hereditary angioedema (HAE) is not available for rapid management of swelling attacks, patients may benefit from fresh frozen plasma (FFP) therapy, according to a ... Read more

October 2, 2020October 2, 2020

Children 6 and Older Can Use Haegarda to Prevent HAE Attacks, FDA Says

Angioedema News

The U.S. Food and Drug Administration (FDA) has extended the use of Haegarda, a C1-INH replacement medication, as a routine treatment to prevent hereditary angioedema (HAE) attacks in children ages ... Read more

September 28, 2020September 28, 2020

Preventive Haegarda Reduces Swelling Attacks in Pediatric HAE Patients, Trial Data Shows

Angioedema News

Preventive treatment with Haegarda, an under-the-skin C1-INH replacement medication by CSL Behring, significantly lowers the number of swelling episodes experienced by children and adolescents with hereditary angioedema (HAE), an analysis ... Read more

September 25, 2020September 25, 2020

Bridge Medicines, Rockefeller Team Up to Develop New Therapy for HAE Type 3

Angioedema News

Bridge Medicines and The Rockefeller University are collaborating to treat hereditary angioedema (HAE) by developing a series of compounds to inhibit the coagulation factor XII, known as FXIIa. Overactive FXIIa ... Read more

September 21, 2020September 21, 2020

Enrollment Completed in Phase 2 Trial of Oral On-demand HAE Therapy KVD900

Angioedema News

The Phase 2 clinical trial testing KalVista Pharmaceuticals‘ oral investigational therapy KVD900 as an on-demand treatment for hereditary angioedema (HAE) attacks has completed enrollment, the company announced. Results from the trial are expected by year’s end. ... Read more

September 18, 2020September 19, 2020

Preventive Berinert Treatment Protects Against Angioedema Attacks After Dental Procedures

Angioedema News

Short-term preventive treatment with Berinert, a plasma-derived form of the C1 inhibitor protein, protects people with hereditary and acquired C1-inhibitor (C1-INH) deficiency from angioedema attacks after dental procedures, according to a ... Read more

September 9, 2020September 10, 2020

Small Hereditary Angioedema Study Supports Efficacy of Ionis’ ASOs

Angioedema News

Antisense oligonucleotides (ASOs) being developed by Ionis Pharmaceuticals may reduce the frequency of attacks in people with hereditary angioedema (HAE), a small study suggests. The study, “Antisense Inhibition of Prekallikrein to ... Read more

August 28, 2020August 28, 2020

Case Study Describes ACE Inhibitor-induced Angioedema in Patient With Plasma Prekallikrein Deficiency

Angioedema News

A case report suggests that the body has multiple ways to produce bradykinin, a molecule that can cause angioedema, in patients taking ACE inhibitors. The report, “Lisinopril-Induced Angioedema in a ... Read more

August 26, 2020September 28, 2020

Xperiome Platform Aims to Streamline Searches for Rare Diseases, Gain Patient Input

Angioedema News

Raremark, an online rare disease patient community, has launched a digital platform called Xperiome, aimed at streamlining the search for new medicines for rare disorders and incorporating more patient input ... Read more

August 21, 2020August 21, 2020

EveryLife Foundation Launches Scholarship Fund for Rare Disease Community in US

Angioedema News

The EveryLife Foundation for Rare Diseases has launched a scholarship fund in the U.S. to support individuals with rare disorders who are pursuing personal goals through training and education. The ... Read more

August 19, 2020August 19, 2020

Orladeyo Set to Launch by Year’s End if Approved, BioCryst Says

Angioedema News

BioCryst Pharmaceuticals is prepared to launch Orladeyo (berotralstat), an oral treatment for hereditary angioedema (HAE), by the end of the year if the medication is approved, the company has announced. ... Read more

August 12, 2020September 13, 2020

New Streaming Channel Showcases Rare Disease Films

Angioedema News, COVID-19 News

When the COVID-19 pandemic forced the postponement of a rare disease film festival originally slated for May, its organizers set out to find a new way to bring the films ... Read more