ANCA Vasculitis News

November 30, 2020November 30, 2020

NORD Push for Rare Disease Advisory Councils Focus of Dec. 16 Public Meeting

To empower and equip members of the rare disease community to engage state leaders in matters of importance to patients and their families, the National Organization for Rare Disorders (NORD) ... Read more

November 25, 2020November 25, 2020

IPF Risk Genes Linked to AAV in Study, But Not to AAV-associated Lung Disease

ANCA Vasculitis News

Genetic variations in the TERT and DSP genes, previously associated with an increased risk of idiopathic pulmonary fibrosis (IPF), are also tied to a greater likelihood of ANCA-associated vasculitis (AAV), a study in ... Read more

November 18, 2020November 18, 2020

Monitoring Autoantibodies in AAV Helps Predict Remission, Relapse, Study Finds

ANCA Vasculitis News

Changes in autoantibodies that target the protein PR3 in people with ANCA-associated vasculitis (AAV) may help predict sustained remission following treatment, and eventual disease relapses, a study found. The research ... Read more

November 16, 2020November 16, 2020

Oral Avacopan Improves Kidney Function and Delays Relapse, Trial Reports

ANCA Vasculitis News

Avacopan is superior to prednisone at improving kidney health in people with ANCA-associated vasculitis (AAV) and poor kidney function, and in extending time until a disease relapse, new data from a Phase ... Read more

November 11, 2020November 11, 2020

Measuring mCRP Levels May Help Identify Cardiovascular Disease in AAV Patients

ANCA Vasculitis News

Measuring the level of C-reactive protein monomer (mCRP) — a protein that increases in response to tissue damage and inflammation — may help identify those ANCA-associated vasculitis (AAV) patients who ... Read more

November 9, 2020November 10, 2020

Oral Therapy Avacopan for AAV Now Under Regulatory Review in Europe

ANCA Vasculitis News

The European Medicines Agency (EMA) has agreed to review Vifor Pharma and ChemoCentryx’s application requesting the approval of avacopan to treat granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), the ... Read more

October 28, 2020November 30, 2020

UK Organization ‘Same But Different’ Announces ‘Glimmer of Hope’ Photo Contest Winner

ANCA Vasculitis News

A photo of a bespectacled young boy, his red baseball cap slightly askew as he enjoys time outside, will be featured on the front cover of an upcoming calendar in ... Read more

October 26, 2020October 27, 2020

AAV Patients Not at Greater COVID-19 Risk, But Care Is Disrupted Due to Pandemic

ANCA Vasculitis News, COVID-19 News

People with ANCA-associated vasculitis (AAV) have a similar incidence of COVID-19 as the general population, but the ongoing pandemic has significantly disrupted routine medical care for patients with this autoimmune ... Read more

October 21, 2020October 21, 2020

High Relapse Risk Found in AAV Patients With Recurrent or Persistent ANCA Antibodies

ANCA Vasculitis News

Having persistently or recurrently high levels of ANCA antibodies is associated with a greater risk of relapse in people with ANCA-associated vasculitis (AAV), a recent study has found. In patients ... Read more

October 19, 2020November 20, 2020

Telehealth ‘Helpful’ Alternative to In-person Care, Rare Disease Patients Say

ANCA Vasculitis News, COVID-19 News

A majority of rare disease patients using telehealth during the COVID-19 pandemic thought the experience positive, and many would like the option of continuing its use in future appointments, a series ... Read more

October 14, 2020October 14, 2020

ANCA Patients With Kidney Inflammation at High Risk for VTE Blood Clots

ANCA Vasculitis News

People with kidney inflammation due to ANCA-associated vasculitis (AAV) have a high incidence of venous thromboembolism or VTE, a potentially dangerous type of blood clot, a new study shows. However, ... Read more

October 12, 2020October 12, 2020

Heat Shock Proteins in Kidneys Linked to Poorer Outcomes in AAV Patients

ANCA Vasculitis News

A group of proteins that modulate immune responses, called heat shock proteins (HSPs), are significantly elevated in the kidneys of people with ANCA-associated vasculitis (AAV), and their levels are associated ... Read more

October 7, 2020November 8, 2020

Same But Different Asks Public to Vote on ‘Glimmer of Hope’ Calendar Photos

ANCA Vasculitis News, COVID-19 News

Same But Different, a nonprofit U.K. group that uses art for social change, is inviting people to choose their favorite photographs in a calendar contest to heighten awareness of rare diseases, ... Read more

September 30, 2020September 30, 2020

Plasma Exchange Shows Little Benefit in AAV Treatment, Meta-analysis Finds

ANCA Vasculitis News

Adding plasma exchange to immune-suppressing treatment does not significantly improve clinical outcomes in people with ANCA-associated vasculitis (AAV), a new meta-analysis indicates. The analysis, “The role of plasma exchange in ... Read more

September 28, 2020September 28, 2020

B-cells Marker Levels May Predict Complete Responses to Rituximab in GPA, MPA

ANCA Vasculitis News

High blood levels of FCRL5 — a protein mainly found in certain B-cells, a type of immune cell — are linked with a greater likelihood of achieving and maintaining a ... Read more