ALS News Today

August 10, 2020August 10, 2020

AC Immune Working to Move TDP-43 Antibody Into Clinical Testing for ALS

ALS News Today

AC Immune is planning to advance its investigational anti-TDP-43 antibody into clinical testing for neurodegenerative diseases, like amyotrophic lateral sclerosis (ALS), in which TPD-43 protein aggregates play a major role ... Read more

August 7, 2020August 7, 2020

Paper Explores Whether Lou Gehrig Experienced a Temporary ALS Reversal in 1938

ALS News Today

For three weeks during Lou Gehrig’s final season, the baseball legend appeared to shake off his symptoms of amyotrophic lateral sclerosis (ALS) and regain his flagging prowess. Richard Bedlack, MD, ... Read more

August 6, 2020August 6, 2020

First Patients Enrolled in Pivotal HEALEY ALS Trial of Multiple Therapies

ALS News Today

The first platform trial for amyotrophic lateral sclerosis (ALS), designed to assess multiple treatment candidates simultaneously with a goal of accelerating the development of ALS therapies, has enrolled its first ... Read more

August 5, 2020August 5, 2020

AstroRx Slows ALS Progression at All Doses Tested, Trial Shows

ALS News Today, COVID-19 News

Kadimastem’s cell therapy candidate, AstroRx, significantly lowers the rate of disease progression in people with amyotrophic lateral sclerosis (ALS) for at least three months after treatment, updated findings from the company’s ... Read more

August 4, 2020August 4, 2020

ALS Researchers Probe Cerebrospinal Fluid’s Role in Motor Neurons

ALS News Today

The clear, colorless liquid that fills and surrounds the brain and spinal cord in people with amyotrophic lateral sclerosis (ALS) seems to induce early neurodegeneration events in healthy motor neurons, ... Read more

August 3, 2020August 3, 2020

Stem Cell Treatment Seen to Safely Aid Speech in ALS Patients in Small Study

ALS News Today

Stem cells collected from a patient’s bone marrow and infused into the spinal fluid safely improved speaking abilities after 28 days for most of the 12 adults with amyotrophic lateral sclerosis ... Read more

July 31, 2020July 31, 2020

Study Probes Gut Microbiome Alterations, Probiotics in ALS Patients

ALS News Today

The gut microbiome in people with amyotrophic lateral sclerosis (ALS) is altered compared to healthy people, which includes an imbalance in potentially protective microbial groups and others with pro-inflammatory activity, ... Read more

July 30, 2020July 30, 2020

Phase 3 Update: Levosimendan Fails to Ease Breathing Problems in ALS Patients

ALS News Today

Orion Corporation’s oral therapy levosimendan (ODM-109) failed to preserve lung function and overall functionality in people with amyotrophic lateral sclerosis (ALS), data from the Phase 3 REFALS clinical trial show. “We would ... Read more

July 29, 2020July 29, 2020

Ultrasound Measures of Muscle May Help in Diagnosing, Evaluating ALS

ALS News Today

Measurements taken of muscle using ultrasound could be useful in diagnosing or managing amyotrophic lateral sclerosis (ALS), a small study suggests. The study, “Application of Muscle Ultrasound for the evaluation of ... Read more

July 28, 2020July 28, 2020

Stress-sensing Molecule May Be Potential Therapeutic Target in ALS

ALS News Today

A small molecule called microRNA-182-5p (miR‐182‐5p) is involved in the detection of cell stress and in the survival of motor neurons, the cells progressively lost in people in amyotrophic lateral sclerosis (ALS), ... Read more

July 27, 2020July 28, 2020

New FUS Mutation Linked to Aggressive ALS in Teenage Girl

ALS News Today

A new mutation in the FUS gene, which results in a shorter version of the FUS protein that cannot enter the cell nucleus to work as it should, may cause an aggressive ... Read more

July 24, 2020July 24, 2020

Gene Silencing Method Shows Promise to Treat Familial ALS Associated With SOD1 Mutations

ALS News Today

A single dose of an artificial microRNA — a tiny RNA molecule that is able to control the activity of certain genes — can lower the activity of SOD1, a gene ... Read more

July 23, 2020July 23, 2020

Common Blood Biomarker Changes Linked to ALS Progression, Study Determines

ALS News Today

Changes in commonly tested blood biomarkers in people with amyotrophic lateral sclerosis (ALS) may be associated with faster disease progression and an increased risk of mortality, according to a recent ... Read more

July 22, 2020July 22, 2020

Tofersen Safe, Appears to Slow Disease Progression in SOD1 ALS Patients, Phase 1/2 Trial Shows

ALS News Today

Tofersen, Biogen’s investigational therapy for people with familial amyotrophic lateral sclerosis (ALS) caused by SOD1 gene mutations, was safe and generally well-tolerated over three months, and appeared to lower SOD1 protein levels in the central ... Read more

July 21, 2020July 21, 2020

Study Finds Higher Risk of Prolonged Grief Among Bereaved Caregivers of MND Patients

ALS News Today

Bereaved caregivers of people with motor neurone disease (MND) are at increased risk of prolonged grief disorder compared to the general bereaved population, a new study suggests. This indicates a need for ... Read more