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University of Sheffield Partners With Aclipse to Advance ALS Treatment M102 to Clinical Trial
M102, a potential treatment for amyotrophic lateral sclerosis (ALS), is advancing into its first clinical ...
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Japan Grants Patent to Brainstorm Covering Technique for NurOwn
The Japan Patent Office has granted a patent to Brainstorm Cell Therapeutics covering the proprietary ... -
FightMND Grant Awards Further Work Into ALS, Other Motor Neuron Diseases
Three grants given researchers at two centers in Australia will advance work into ways of ... -
When We Do Something, Something Happens
Hang on tightly, it’s another week of weather events, news alerts, and a continuing health ... -
$1.9M NIH Grant Supports Study of Ways to Preserve Swallowing, Breathing
The National Institutes of Health (NIH) has awarded a $1.9 million grant to University of ... -
Novus Acquires Anelixis, Plans to Move AT-1501 Into Phase 2 Trial for ALS
Novus Therapeutics has acquired Anelixis Therapeutics and its portfolio, including the antibody AT-1501, a potential treatment for amyotrophic ... -
Former NFL Player, Microsoft Team to Make Technology More Accessible
Microsoft opened its 2014 Super Bowl ad with the question: “What is technology?” As Steve Gleason, an ... -
The Burden of Knowing the Future
Lulu Wang’s film “The Farewell” is based on an actual lie. The 2019 comedic drama ... -
Investigational Treatment IPL344 Safely Slows ALS Progression in Small Phase 1/2a Trial
IPL344, Immunity Pharma‘s investigational therapy for amyotrophic lateral sclerosis (ALS), has a positive safety and tolerability ... -
Dosing Begins in Phase 2a Study of ALZT-OP1a for Mild-to-Moderate ALS
The first patient has been dosed in a Phase 2a clinical trial evaluating the safety ... -
Things to Do While Waiting for a Cure
Big news buzzed through the ALS community last week about AMX0035, an investigational treatment for ... -
Helixmith Planning Phase 2 Trial of Engensis, Potential Gene Therapy for ALS
Helixmith has selected Worldwide Clinical Trials to run a planned Phase 2 study of Engensis (VM202), ... -
PrimeC Shows Potential to Slow ALS Progression, Interim Data Reveal
PrimeC is safe and well-tolerated for the treatment of amyotrophic lateral sclerosis (ALS) and shows ... -
Study Describes New Compounds With Potential to Treat ALS
Newly developed compounds derived from ebselen could be used to treat some types of amyotrophic ... -
Gaining Perspective Through Journaling
Perspective can be hard to come by with ALS, but writing has helped me keep ... -
RESCUE-ALS Phase 2 Trial Completes Enrollment Ahead of Schedule
Patient enrollment is now complete for the Phase 2 clinical trial of Clene Nanomedicine‘s CNM-Au8 as a ... -
ALS Community Invited to Join Petition Calling on FDA to Approve AMX0035
The ALS Association and I AM ALS have opened a petition calling for the earliest possible approval of ... -
ALS Community Invited to Join Petition Calling on FDA to Approve AMX0035
The ALS Association and I AM ALS have opened a petition calling for the earliest possible approval of ... -
Learning to Pivot When Living With ALS
All around me, I’ve been noticing how people, businesses, and organizations are pivoting to survive ... -
Learning to Pivot When Living With ALS
All around me, I’ve been noticing how people, businesses, and organizations are pivoting to survive ... -
Cause of WWII-era ALS Cluster on Guam May Be Younger Cycad Seeds
Younger cycad seeds can contain more toxins than older seeds, and their widespread consumption by ... -
Cause of WWII-era ALS Cluster on Guam May Be Younger Cycad Seeds
Younger cycad seeds can contain more toxins than older seeds, and their widespread consumption by ... -
First Patient Enrolled in Phase 1 Gene Therapy Study in Ireland
A Phase 1 clinical trial of a gene-based therapy for amyotrophic lateral sclerosis (ALS) is now ... -
First Patient Enrolled in Phase 1 Gene Therapy Study in Ireland
A Phase 1 clinical trial of a gene-based therapy for amyotrophic lateral sclerosis (ALS) is now ... -
AMX0035 Safe, Effective in Slowing ALS Functional Decline, Trial Data Shows
Amylyx’s experimental oral treatment AMX0035 safely and effectively slows functional decline in amyotrophic lateral sclerosis (ALS) patients with ... -
AMX0035 Safe, Effective in Slowing ALS Functional Decline, Trial Data Shows
Amylyx’s experimental oral treatment AMX0035 safely and effectively slows functional decline in amyotrophic lateral sclerosis (ALS) patients with ... -
Now, Our Favorite Restaurant Is Inaccessible to All
My husband, Todd, and I celebrated our 17th wedding anniversary in late August with a ... -
Now, Our Favorite Restaurant Is Inaccessible to All
My husband, Todd, and I celebrated our 17th wedding anniversary in late August with a ... -
Phase 3 Study of Oral Edaravone for ALS Resumes Patient Enrollment
The Phase 3 clinical trial testing an oral suspension formulation of edaravone for amyotrophic lateral sclerosis (ALS) has ... -
Phase 3 Study of Oral Edaravone for ALS Resumes Patient Enrollment
The Phase 3 clinical trial testing an oral suspension formulation of edaravone for amyotrophic lateral sclerosis (ALS) has ... -
Same But Different Photo Contest Celebrates People With Rare Diseases
Same But Different, a U.K. nonprofit that uses the arts to bring communities together, is ... -
Going With My Gut
Looking forward to getting a flu shot is something I never thought possible. But at ... -
Going With My Gut
Looking forward to getting a flu shot is something I never thought possible. But at ... -
C9orf72 Mutations Lead to Increased Immune Activity, Mouse Study Suggests
Mutations in the gene C9orf72, a common genetic cause of amyotrophic lateral sclerosis (ALS), cause immune ... -
C9orf72 Mutations Lead to Increased Immune Activity, Mouse Study Suggests
Mutations in the gene C9orf72, a common genetic cause of amyotrophic lateral sclerosis (ALS), cause immune ... -
ILB, Potential ALS Therapy in Phase 2 Trial,Named Orphan Drug in Europe
The European Commission has granted orphan drug designation to ILB, Tikomed‘s investigational treatment for amyotrophic ... -
ILB, Potential ALS Therapy in Phase 2 Trial,Named Orphan Drug in Europe
The European Commission has granted orphan drug designation to ILB, Tikomed‘s investigational treatment for amyotrophic ... -
Prosetin Granted Orphan Drug Designation for ALS
The U.S. Food and Drug Administration has granted Prosetin orphan drug designation for the treatment of ... -
Prosetin Granted Orphan Drug Designation for ALS
The U.S. Food and Drug Administration has granted Prosetin orphan drug designation for the treatment of ... -
Friends Who Can Handle Chronic Illness
In his book “Out of Solitude,” Henri Nouwen writes, “When we honestly ask ourselves which ... -
Friends Who Can Handle Chronic Illness
In his book “Out of Solitude,” Henri Nouwen writes, “When we honestly ask ourselves which ... -
Pharnext’s PXT864 Shows Promising Neuroprotective Effects in ALS, Early Study Shows
Pharnext’s investigational oral combination therapy PXT864 prevents degeneration of motor neurons and their point of ... -
Finding Sweetness in the Eye of the Storm
Just like Lionel Barrymore as James Temple in “Key Largo“ and Gary Sinise as Lt. ... -
Finding Sweetness in the Eye of the Storm
Just like Lionel Barrymore as James Temple in “Key Largo“ and Gary Sinise as Lt. ... -
Health Insurance, Cost of ALS Care Add to Disease Burden in US, Survey Finds
Accessing and understanding insurance coverage, and paying for medical treatments and services top the list ... -
Getting Back to the Basics of Mindfulness
Recently, I noticed I was having problems keeping track of time. Not clock time, as ... -
Getting Back to the Basics of Mindfulness
Recently, I noticed I was having problems keeping track of time. Not clock time, as ... -
New Telehealth App Connects Those With Motor Neuron Disease to Carers in UK
A new telehealth app to help people with motor neuron diseases such as amyotrophic lateral ... -
UK Program Aims to Help Children of Families Touched by ALS
Two U.K. organizations, the Motor Neurone Disease (MND) Association and Nick Smith Foundation, are partnering on ... -
NurOwn Promotes Immunoregulation, Lessens Inflammation
BrainStorm Cell Therapeutics’ cell-based therapy NurOwn increases the number of immunosuppressive cells and lessens inflammation, ... -
Taking Care of Unfinished Business
“That’s the one project I wish I could have finished,” my husband, Todd, said while ... -
Taking Care of Unfinished Business
“That’s the one project I wish I could have finished,” my husband, Todd, said while ... -
Clinical Research ‘Dashboard’ Brings Latest on ALS Trials to Patients
The nonprofit group I AM ALS has opened a global resource to help keep amyotrophic lateral sclerosis ... -
Learning to Cherish a Room With a View
Last week, I ended this column with a tongue-in-cheek inference that in deference to an ... -
Learning to Cherish a Room With a View
Last week, I ended this column with a tongue-in-cheek inference that in deference to an ... -
Jane Calmes ALS Scholarship Awards Given to 94 Students Across US
The ALS Association has awarded $470,000 in scholarships to 94 students in the U.S. whose ... -
3 New Ways to Stay Energized
What a long, crazy summer it’s been, as we’re living with minimal social interaction and ... -
3 New Ways to Stay Energized
What a long, crazy summer it’s been, as we’re living with minimal social interaction and ... -
Inhibition of RAGE Protein Lessens ALS Symptoms in Mice, Study Finds
Inhibiting the receptor for advanced glycation end products (RAGE) protein lessens the symptoms of amyotrophic lateral ... -
Innovate UK Grant Supports Early Work on Cell Therapy for ALS
Innovate UK has given a grant to Reflection Therapeutics to help fund research into new ways ... -
New ALS Chip Model Closely Mimics Disease, May Aid Research
Researchers report having created a new human-on-a-chip model, one able to more accurately simulate the ... -
Just Showing Up Is an Accomplishment
Years before my husband was diagnosed with ALS, I coordinated a tutoring program in Milwaukee. ... -
Nerve Cell Injury and Chronic Inflammation Need Be Focus of ALS Research
The greater incidence of amyotrophic lateral sclerosis (ALS) among professional athletes and people with head ... -
Is It a Jinx or a Sphinx?
“You don’t tug on Superman’s cape, You don’t spit into the wind, You don’t pull ... -
Seelos to Proceed With Phase 2b/3 Trial Investigating SLS-005 for ALS
Seelos Therapeutics has received a notification from the U.S. Food and Drug Administration (FDA) permitting ... -
Aural Analytics’ Speech Technology Added to HEALEY ALS Platform Trial
Aural Analytics’ speech-based digital technology will be used to measure changes in speech in people ... -
AC Immune Working to Move TDP-43 Antibody Into Clinical Testing for ALS
AC Immune is planning to advance its investigational anti-TDP-43 antibody into clinical testing for neurodegenerative ... -
Paper Explores Whether Lou Gehrig Experienced a Temporary ALS Reversal in 1938
For three weeks during Lou Gehrig’s final season, the baseball legend appeared to shake off ... -
Train Your Eyes to Find the Light
Weeks after my husband’s ALS diagnosis, we were still in shock, but we mustered ourselves ... -
First Patients Enrolled in Pivotal HEALEY ALS Trial of Multiple Therapies
The first platform trial for amyotrophic lateral sclerosis (ALS), designed to assess multiple treatment candidates ... -
Navigating an Uncertain (Lega) Sea
“The world will little note, nor long remember …” These words of Abraham Lincoln were ... -
AstroRx Slows ALS Progression at All Doses Tested, Trial Shows
Kadimastem’s cell therapy candidate, AstroRx, significantly lowers the rate of disease progression in people with amyotrophic ... -
Taming My Runaway Thinking
Racing thoughts, runaway thoughts. Whatever you call ’em, I caught ’em. Yup, a case of ... -
ALS Researchers Probe Cerebrospinal Fluid’s Role in Motor Neurons
The clear, colorless liquid that fills and surrounds the brain and spinal cord in people ... -
Stem Cell Treatment Seen to Safely Aid Speech in ALS Patients in Small Study
Stem cells collected from a patient’s bone marrow and infused into the spinal fluid safely ... -
Study Probes Gut Microbiome Alterations, Probiotics in ALS Patients
The gut microbiome in people with amyotrophic lateral sclerosis (ALS) is altered compared to healthy ... -
Snapshots of Life With ALS
“Thank God I didn’t have to cough this weekend,” my husband, Todd, said after his ... -
Phase 3 Update: Levosimendan Fails to Ease Breathing Problems in ALS Patients
Orion Corporation’s oral therapy levosimendan (ODM-109) failed to preserve lung function and overall functionality in people ... -
Ultrasound Measures of Muscle May Help in Diagnosing, Evaluating ALS
Measurements taken of muscle using ultrasound could be useful in diagnosing or managing amyotrophic lateral sclerosis ... -
Knitting My Way to a Solution for the Chills
Last week, I had the pleasure of joining the Fox Valley/Lakeshore ALS Virtual Support Group ... -
Stress-sensing Molecule May Be Potential Therapeutic Target in ALS
A small molecule called microRNA-182-5p (miR‐182‐5p) is involved in the detection of cell stress and ... -
New FUS Mutation Linked to Aggressive ALS in Teenage Girl
A new mutation in the FUS gene, which results in a shorter version of the FUS protein ... -
Gene Silencing Method Shows Promise to Treat Familial ALS Associated With SOD1 Mutations
A single dose of an artificial microRNA — a tiny RNA molecule that is able ... -
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Common Blood Biomarker Changes Linked to ALS Progression, Study Determines
Changes in commonly tested blood biomarkers in people with amyotrophic lateral sclerosis (ALS) may be ... -
The Absurdity of a Progressively Debilitating Terminal Illness
“Oh, I used to be disgusted and now I try to be amused.” Those lyrics ... -
Tofersen Safe, Appears to Slow Disease Progression in SOD1 ALS Patients, Phase 1/2 Trial Shows
Tofersen, Biogen’s investigational therapy for people with familial amyotrophic lateral sclerosis (ALS) caused by SOD1 gene mutations, was safe ... -
Let’s Go to the Movies
During these past few months, like most folks I know, I’ve been watching movies — ... -
Study Finds Higher Risk of Prolonged Grief Among Bereaved Caregivers of MND Patients
Bereaved caregivers of people with motor neurone disease (MND) are at increased risk of prolonged grief ... -
Slower Progression Seen in US Veterans Living Longer Than Disease Norm
A comparison of amyotrophic lateral sclerosis (ALS) among U.S. military veterans found those who lived ... -
Cancer Immunotherapy Aldesleukin Shows Promise for ALS in Pivotal Trial
Low doses of Clinigen’s aldesleukin, an immunotherapy used in certain types of cancer, safely boosted ... -
Expanding World, Shrinking World
When I was a child, my elderly great-aunt Martha joined my family every Christmas Eve ... -
ALS Association Grant Sustains HudsonAlpha Institute, Crestwood Medical Center Project
The HudsonAlpha Institute for Biotechnology has received a $20,000 ALS Association grant to continue its research ... -
Taking Baby Steps in Search of a Cure
“Baby steps.” That was the advice imparted to Bob Wiley by his psychiatrist, Dr. Leo ... -
microRNA Sequences Work as ‘Fingerprints’ for Early ALS Diagnosis, Study Says
microRNAs found in brain-derived exosomes — microscopic vesicles containing genetic material, proteins and fats shed by cells ... -
Checking In on My Life With ALS During Lockdown
Oh my! We’re still facing challenges brought on by the pandemic and most likely will ... -
Clinigen’s Aldesleukin Earns FDA’s Orphan Drug Designation as ALS Treatment
The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to Clinigen’s aldesleukin for ... -
2 Proteins Seen as Possible ALS Blood Biomarkers
Clusterin, a protein that plays a key role in motor neuron health, and ficolin-3, a ... -
Diagnostic Delays in ALS ‘Surprisingly Large’ and Need Not Be, Study Says
Long delays between symptom onset and diagnosis are common with amyotrophic lateral sclerosis (ALS), and ... -
Making Mental Notes While He’s Still Here
After our second child was born — back when my husband, Todd, had an undiagnosed ... -
QurAlis Licenses Eli Lilly’s Preclinical Compounds That Target Neuronal Excitotoxicity
QurAlis Corporation has licensed preclinical small molecule compounds — designed to treat amyotrophic lateral sclerosis ... -
Eye-tracking Device Gives Voice to ALS Ice Bucket Challenge Co-founder Pat Quinn
For Pat Quinn, co-founder of the ALS Ice Bucket Challenge, everyday communication has become more ... -
Study Examines Barriers to Social Prescribing for People With Motor Neurone Disease
Barriers need to be overcome in order to facilitate community engagement programs for people with ... -
200 ALS Patients Finish Dosing in Phase 3 Trial of NurOwn Cell Therapy
Patient dosing has finished in the pivotal Phase 3 trial assessing the safety and efficacy ... -
Learning How to Help from 5 Phone Calls
Nine months after my husband, Todd, was diagnosed with ALS, he entered a social media ... -
Severe Weight Loss Linked to Higher Risk of Death in Study of Patients
Weight loss at the time of diagnosis appears common among people with amyotrophic lateral sclerosis (ALS), regardless ... -
‘Bar Code’ Identifies Nervous System Cells That May Be Key to Treating ALS
Scientists have identified molecules that enable them to study and manipulate a specific type of ... -
My Cuisine Adventures While Living with ALS
Recently, my husband and I experienced a staycation of sorts — we dined on two ... -
Compound Found in Blackberries Prolongs Lifespan, Reduces Disease Severity in ALS Mice
Protocatechuic acid, a metabolite of one of the main substances that give blackberries and black ... -
Research Aims to Help Advanced ALS Patients Communicate More Easily
A research project underway at the University of Rhode Island (URI) aims to help people ... -
Non-Coding RNA May Serve as Blood-based Biomarker for ALS
Distinct RNA patterns in a person’s blood may signal the presence of amyotrophic lateral sclerosis ... -
An Old Dog Teaches Me New Tricks
I found a walking buddy, and he’s teaching me how to live with my husband’s ... -
Radicava Added to Public Health Plans of Ontario, Brunswick and Alberta
Three Canadian provinces — Ontario, New Brunswick, and Alberta — have added Radicava (edaravone), a treatment for ... -
Oh My God — I Have ALS
The lyrics to “God Shuffled His Feet,” a song by the Canadian band Crash Test ... -
Lifelong Exercise May Limit Brain’s Ability to Adapt in ALS, Study Suggests
Amyotrophic lateral sclerosis (ALS) patients who never regularly engaged in sports or physical activity have ... -
ALS Support Groups Are Going Online
Last week, I joined about 20 other ALS patients in attending an online meeting on ... -
ALS Patients Show Altered Levels of Iron Status Indicators, Study Reports
The levels of certain indicators of iron status, namely ferritin and transferrin, are altered in ... -
NIH Earmarks $25M for Five-year Program Promoting ALS Research
The National Institutes of Health (NIH) is investing $25 million over five years in a ... -
NIH Grant Supports Work Into Cause of TDP-43 Protein Clumps in ALS, Alzheimer’s
The National Institutes of Health (NIH) has awarded a $3.3 million grant to researchers at ... -
Hanging Up the Keys and Other Tough Decisions
I thought my husband, Todd, should quit driving long before he was ready to hang ... -
Caffeine and NAD+ Bolster Health of Motor Neurons From ALS Mouse Model
Caffeine, an antioxidant with neuroprotective properties, was seen to promote the normal development of lab-cultured ... -
‘What’s Love Got to Do With It?’
“Without your love, I’d be nowhere at all. I’d be lost if not for you.” ... -
Global Day 2020 Calls Attention to ALS and Need for Better Care
Each June 21 marks Global Day 2020, 24 hours set aside to heighten awareness of ... -
Researchers Identify New Genetic Defect Linked to ALS
Mutations in the UBQLN2 gene, known to cause amyotrophic lateral sclerosis (ALS), promote the buildup ... -
Studies of DNL747 Paused, Work Shifts to Possibly Better Treatment
Denali Therapeutics and Sanofi announced a pause in clinical testing of their small molecule inhibitor ... -
NEK1 Gene Variants Increase Odds of Developing ALS, Study Finds
Genetic variants of the NEK1 gene that cause the coded protein to lose its function ... -
Caregivers Are Only Human
Ten years ago today, my husband, Todd, was diagnosed with ALS. I’m grateful that our ... -
BrainStorm Awarded $500K from ALS Association, I AM ALS to Support Biomarker Research
The ALS Association and I AM ALS have awarded BrainStorm Cell Therapeutics $500,000 to support ... -
ALS, Before and After
Author T. H. White‘s collection of novels titled “The Once and Future King” depicts the ... -
Tamoxifen Shows Modest Effects in ALS Patients, Phase 1/2 Trial Finds
A cancer treatment called tamoxifen, which previously showed promise in preclinical studies for the treatment ... -
Celebrating 3 Years of ‘Living Well with ALS’
This week, I’m celebrating my third anniversary of writing columns for ALS News Today. This ... -
Woman’s ALS-like Symptoms Linked to Retrovirus in Case Report
Treatment of people whose symptoms are suggestive of amyotrophic lateral sclerosis (ALS) but likely linked ... -
Teeth of ALS Patients Show Odd Metabolism of Metals in Childhood
The teeth of people with amyotrophic lateral sclerosis (ALS) show their bodies metabolize metals — ... -
Results of Phase 3 Trial of NurOwn Cell Therapy Expected by End of Year
The pivotal Phase 3 clinical trial testing BrainStorm Cell Therapeutic’s cell-based therapy NurOwn in amyotrophic ... -
Applying the Science of Happiness to Caregiving
I cried buckets in the months after my husband, Todd, was diagnosed with ALS. When ... -
Statins Not Linked to Earlier Death Among ALS Patients in Registry Study
Statins, often prescribed to lower cholesterol levels, are not associated with poorer overall survival in ... -
Houston, We Have a Problem
The hubbub percolating around the SpaceX launch last weekend reminded me of the role a ... -
Legislation Seeks Early Access to Promising Treatments for ALS, Similar Disorders
Two bills making their way through Congress are intended to improve access to medical therapies ... -
How I Navigate My ‘ALS Time Zone’
During my past 10 years of living with ALS, I’ve had to adapt to a ... -
COVID-19 Challenges ALS Care, But Telemedicine a Vast Opportunity
The COVID-19 pandemic has imposed new challenges on diagnosing, monitoring, and caring for people with ... -
Ventilator Adaptations Crucial for ALS Patients During COVID-19, Scientists Say
For people with amyotrophic lateral sclerosis (ALS) currently on non-invasive ventilation, modifications to existing equipment ... -
RESCUE-ALS Trial Enrolls More Than Half of Patients Ahead of Schedule
The Phase 2 clinical trial investigating Clene Nanomedicine‘s CNM-Au8 as a potentially disease-modifying therapy for people ... -
‘Graves Are for the Living’
On Memorial Day, my mom, the kids, and I visited Lakeside Cemetery in Hancock, Michigan. ... -
Mitsubishi Tanabe Opens Phone Support for Those Interested in Radicava
Mitsubishi Tanabe Pharma America (MTPA) has set up a support program for adults living with amyotrophic ... -
My Face Mask Blocks More Than COVID-19
A large part of successfully living with ALS is to face each challenge with a positive ... -
Arimoclomol Earns FDA’s Fast Track Status for ALS
The U.S. Food and Drug Administration (FDA) has given fast track designation to Orphazyme’s investigational therapy arimoclomol ... -
High Creatinine Kinase Levels Predict Slower Progression in ALS, Study Finds
Levels of creatinine kinase — a marker of muscle damage — are elevated in most amyotrophic lateral ... -
Let’s Just Call It Love
A few years before my husband, Todd, was diagnosed with ALS, he baked a cake ... -
Gut Microbiota Affects Inflammation and Lifespan in ALS, Mouse Study Shows
Changing the composition of bacteria in the gut using antibiotics or fecal transplants may help ... -
A Typical Day in My Life with ALS
“Woke up, fell out of bed, dragged a comb across my head.” These are the ... -
Cerebrospinal Fluid May Transport ALS Toxins, Mouse Study Suggests
The clear, colorless liquid that fills and surrounds the brain and spinal cord may spread ... -
My A-L-S Word Game
Here’s a fun challenge. In the spirit of celebrating ALS Awareness Month, I invite you ... -
Neurotoxin of Blue-Green Algal Blooms May Raise Risk of ALS
Exposure to a neurotoxic molecule produced by blue-green algae seems to raise a person’s odds ... -
Rare Variants in TET2 Gene May Double Person’s Risk of ALS, Similar Ills
Rare variations in the TET2 gene seem to double a person’s risk of multiple neurodegenerative ... -
NurOwn May Curb Damaging Brain Inflammation in ALS Patients, Study Suggests
NurOwn, a cell-based therapy that protects and helps repair nerve cells, also may be able ... -
An Unexpected Delivery Full of Love
As I waited for the postmaster to bring my package to the counter, I tried ... -
ProMIS Creating Intrabodies, Antibodies Targeting Protein Clumps Within Cells
ProMIS Neurosciences announced its program for amyotrophic lateral sclerosis (ALS) is advancing, and scientists were able to ... -
The Monster that ALS Is
Donald Rumsfeld, the former U.S. Secretary of Defense, once stated at a Defense Department briefing ... -
WSU Students Design Mattress to Help ALS Patients Sleep Better
A student bioengineering team at Washington State University (WSU) has designed a mattress to help ... -
Reimagining the Rollator
Did you know that rollators were invented nearly 40 years ago? A Swedish woman with ... -
Pandemic Moves ALS Awareness Month Events and Activities Online
ALS Awareness Month has been observed each May since 1992. But this year, the COVID-19 pandemic ... -
Target ALS, AFTD Award $5M to Support Research Projects
Grant awards totaling $5 million will support six academic-industry projects into potential biomarkers and treatments for amyotrophic ... -
Agriculture Work and Exposure to Pollutants May Raise ALS Risk
Agriculture and other areas that expose people to pesticides, paint solvents, electromagnetic fields, and heavy ... -
Stories Connect Us in ALS Awareness Month
For a couple years after my husband Todd’s ALS diagnosis, I sought companionship in books ... -
ALS Association Supports Mobile App That Tracks Eye Movement to Help Patients
Computer scientists at Stony Brook University have been awarded $200,000 by the ALS Association to ... -
ALS Awareness: What It’s Worth
“I think it’s time we stop, children, what’s that sound? Everybody look what’s going down.” ... -
Blood Biomarkers May Aid in Earlier Diagnosis of ALS, Review Study Suggests
Identifying blood biomarkers that reflect the metabolic changes occurring in people with amyotrophic lateral sclerosis ... -
Get Involved in ALS Awareness Month This May
Release the balloons and cue the marching band! May is ALS Awareness Month! Wait, what? ... -
ALS Association Funding Earmarked to Improve Clinical Trial Infrastructure
The ALS Association has committed $652,543 over the next three years to support efforts to improve the ... -
Radicava Added to Public Health Plan for ALS Patients in Quebec
Quebec has added Radicava (edaravone), Mitsubishi Tanabe Pharma’s treatment for amyotrophic lateral sclerosis (ALS), to its provincial ... -
Loving What’s Left
With my gym closed, I’ve been getting my daily exercise by cross-country skiing. A calm ... -
EMA Favors Giving Amylyx’s AMX0035 Orphan Medicine Status for ALS
A branch of the European Medicines Agency (EMA) has recommended that Amylyx‘s investigational oral compound AMX0035 ... -
Mission Impossible? The Quest for Perpetual ALS Awareness
In 1992 the 102nd U.S. Congress declared, via joint resolution 174, that May become National ... -
Reducing Excess Firing of Motor Neurons Delays Symptoms in Animal Model of ALS
Reducing the excess firing of motor neurons in an animal model of amyotrophic lateral sclerosis ... -
Influencing Mindsets: When to Speak Up About COVID-19 Guidelines
Because I have ALS, I need to minimize the risk of getting the coronavirus. So, ... -
Rowan Team Receives $1.6 Million to Study SOD1 in Gut-brain Communication in Worms
A team at the Rowan University School of Osteopathic Medicine has received a $1.6 million grant ... -
MDA Hosts Facebook Live Event on ALS and COVID-19 on May 1
The Muscular Dystrophy Association (MDA) is hosting a Facebook Live event on May 1 concerning ... -
My Junk Drawer Sparks Memories of Better Days
Since my husband has ALS and is paralyzed, his life is much the same under ... -
Smoking Not Seen to Raise Risk of ALS in UK Study
A weak link only between a person’s current smoking study and greater risk of amyotrophic ... -
Researchers Like Results of Using Nanoparticles to Carry Adapalene in ALS Mice
Injecting tiny particles carrying adapalene — an activator of the retinoic acid signaling pathway — ... -
Pandemic Pitfalls: Avoiding the Compare-despair Trap
Remember those “100 Things to Do During a Pandemic” emails that arrived in our inboxes ... -
NGS, Way of Examining Multiple Genes, May Aid ALS Diagnosis and Study
A way of examining multiple genes or the entire human genome at the same time, called ... -
Problems in Lipid Metabolism Linked to Motor Neuron Disease in Early Study
Changes in the metabolism of a class of fat molecules called sphingolipids may be a ... -
FUS Mutations Cause Most Cases of ALS in Adolescents, Literature Review Finds
When amyotrophic lateral sclerosis (ALS) symptoms emerge during adolescence, mutations in the FUS gene are ... -
‘How Are You?’ Can Be a Weighty Question
When someone asks how I am in passing, I know the script: “I’m fine. How ... -
Plasma Creatinine Potential Biomarker of Functional Decline, Survival in ALS Patients, Study Indicates
Levels of plasma creatinine — a metabolic product of healthy muscle — are significantly associated with ... -
On Planning to Get Punched
“Everybody has a plan until they get punched in the mouth.” –Mike Tyson The author ... -
Shift in Immune Cells’ Balance Linked to ALS Severity and Progression, Study Finds
A shift in the make-up of immune cells found in the blood of patients with ... -
Talking Myself into a New Habit
Recently, I noticed a surprising side effect from just a few weeks of following the ... -
Ionis Scholarship Will Provide Physical and Mental Wellness Programs to ALS Patients
A $25,000 Ionis Pharmaceuticals scholarship will help amyotrophic lateral sclerosis (ALS) patients in the San ... -
Potential Stem Cell Therapy for ALS Moving into Phase 3 Trial
Seneca Biopharma announced that work is underway to advance NSI-566, its leading stem cell treatment candidate, into a ... -
Lower Levels of MicroRNA in ALS Patients Linked to Nerve Cell Damage
People with amyotrophic lateral sclerosis (ALS) have significantly lower levels of a small molecule called ... -
Fasudil Shows Promising Results in 3 ALS Patients Treated Under Compassionate Use
Fasudil, approved in Japan for treating stroke patients, also is well-tolerated and prevents disease worsening ... -
TBK1 Protein Has Dual Role in ALS, First Accelerating It and Later Slowing It
Mutations in the TBK1 gene — often associated with amyotrophic lateral sclerosis (ALS) — seem ... -
Discovery of Link Between Cellular Hallmarks of ALS May Lead to New Therapies
By blocking the activity of the proteasome — a complex of enzymes responsible for the ... -
Age and Sex Strongly Influence ALS Type and Symptoms, Study Finds
The onset and early progression of motor and cognitive symptoms, specific by disease type to ... -
Phase 3 Trial of Masitinib as Add-on ALS Treatment Cleared by FDA
AB Science plans to launch a Phase 3 clinical trial testing the safety and effectiveness of ... -
Brain Mapping Study May Be Used to Help ALS Patients Regain Motor Control
A single brain area previously thought to control only the movement of the hands and ... -
Using Anti-diabetics, Cholesterol-lowering Medicines May Affect Risk of ALS
People with amyotrophic lateral sclerosis (ALS) are less likely to have used anti-diabetic medications in ... -
Radicava Effective in Slowing Progression Across Year of Use, Trial Data Show
Radicava (edaravone), an approved treatment for amyotrophic lateral sclerosis (ALS), can be taken for up ... -
Funding to Boost Clinical Development of Investigational ALS Therapy ILB
Tikomed has secured $5.5 million in financing from investors to support the ongoing clinical development of ILB, ... -
Target ALS and ALS Association to Fund Research on TDP-43’s Potential as ALS Biomarker
Target ALS and The ALS Association will jointly fund two projects focused on the development of ... -
‘Hero’ Proteins Protect Cells from Toxic Clumps Underlying ALS, Other Neurodegenerative Diseases
Human cells produce a type of proteins, termed “Heroes,” that protect against the formation of ... -
Given Proteins in Blood Cells May Be Markers of ALS and Its Likely Course
Levels of specific proteins found in specialized immune cells — white blood cells like lymphocytes ... -
ALS Association Grant to Advance Treatment Aimed at Gut Microbiota
Bloom Science, a biopharmaceutical company, announced it has received a $500,000 grant from The ALS ... -
FAIM Protein Prevents, Reverses Mutant SOD1 Clumping, Study Shows
A molecule that prevents cell death was able to prevent and reverse clumping of a ... -
Stimulating Muscle Cells May Help to Repair Motor Neurons
Muscle cell activity helps to promote motor nerve cell repair after injury, scientists found in ... -
Patients with Milder Weaknesses Show Ability to Drive in Simulator Study
Amyotrophic lateral sclerosis (ALS) patients with mild to moderate disease progression show an ability to ... -
Collaboration Funds Experimental Therapy for Rare FUS-ALS
Eight patients will receive jacifusen, an experimental therapy for amyotrophic lateral sclerosis (ALS) caused by FUS ... -
Animal Studies Targeting Mitochondria Help Prolong Survival, Review Shows
Studies in animal models investigating mitochondrial abnormalities in amyotrophic lateral sclerosis (ALS) found that therapies targeting ... -
Vermont Couple Shares Strategies on Managing Neurodegenerative Disease
Like many couples, Joe and Linda Lacroix of Milton, Vermont, spent much of their lives ... -
Increasing Dok-7 Protein Level May Improve ALS Patients’ Muscle Function, Study Reports
Increasing the production of the muscle protein Dok-7 may be a way to treat the ...