Posts by: Patricia Inacio PhD

Fragile X News Today

Nova Mentis is launching a clinical study in the U.S. to assess the diversity of gut microbiome — the community of microbes living in the gut — in people with ... Read more

March 5, 2021March 5, 2021

Recorlev Up for FDA Approval as Endogenous Cushing’s Syndrome Treatment

Cushing's Disease News

Strongbridge Biopharma has filed an application with the U.S. Food and Drug Administration (FDA) seeking the approval of Recorlev (levoketoconazole) to treat people with endogenous Cushing’s syndrome, the company announced. The application is supported by ... Read more

March 5, 2021March 5, 2021

Keytruda Will No Longer Treat Advanced Small Cell Lung Cancers in US

Immuno-Oncology News

After failing to significantly extend survival in a confirmatory Phase 3 trial, Keytruda (pembrolizumab) will no longer be available in the U.S. for people with previously treated metastatic small cell lung ... Read more

March 4, 2021March 5, 2021

FDA Puts RT001 on Fast Track as Possible FA Therapy

Friedreich's Ataxia News

The U.S. Food and Drug Administration (FDA) has granted rare pediatric disease and fast track designations to Retrotope’s investigational therapy RT001 for the treatment of Friedreich’s ataxia (FA), the company ... Read more

March 4, 2021March 4, 2021

Fox Foundation Grant to Help Advance CNM-Au8 to Planned Phase 2 Trial

Parkinson's News Today

A grant from the Michael J. Fox Foundation (MJFF) will help Clene Nanomedicine to advance in development CNM-Au8, its cellular energy-promoting, investigational Parkinson’s treatment. The grant will help to support preclinical studies in patients’ nerve cells and mouse ... Read more

March 2, 2021March 2, 2021

Dosing Begins in Phase 2 Trial Testing Oral Therapy BBP-418 for LGMD2i

Muscular Dystrophy News

The first patient has been dosed in a Phase 2 trial testing BBP-418, a potential first oral disease-modifying therapy for limb-girdle muscular dystrophy type 2i (LGMD2i). BBP-418 is a small molecule that ... Read more

March 1, 2021March 1, 2021

Changes to Nerve Cell Membrane May Promote Alpha-synuclein’s Toxic Turn

Parkinson's News Today

Changes in the composition of fat molecules on the membranes of nerve cells appear to change how the alpha-synuclein protein interacts with these same cell membranes, possibly promoting the aggregation that characterizes ... Read more

March 1, 2021March 1, 2021

Blood Glucose Levels Appear to Affect Motor Skills and Their Decline

Parkinson's News Today

Abnormal blood sugar (glucose) levels, either lower or higher than the norm, appears to be linked with a faster progression of motor difficulties in people with Parkinson’s disease, research suggests. The ... Read more

March 1, 2021March 1, 2021

Most Vasculitis Patients Willing to Get COVID-19 Vaccine, Survey Finds

ANCA Vasculitis News, COVID-19 News

The majority of people with ANCA-associated vasculitis (AAV) and other forms of vasculitis plan to get the COVID-19 vaccine, and about one-third has already received at least one dose, a ... Read more

February 26, 2021February 26, 2021

Teeth Grinding Is Most Common Dental Problem

Rett Syndrome News

Bruxism, also known as teeth grinding and jaw clenching, is the most common oral manifestation in patients with Rett syndrome, according to a small review of literature. The study, “Oral ... Read more

February 26, 2021February 26, 2021

Severe Neuropathy Could Be Sign of Acute Intermittent Porphyria

Porphyria News

Rapid and severe damage to peripheral nerves, those sending sensory and motor information from the brain and spinal cord to the rest of the body, can be a rare sign ... Read more

February 26, 2021February 26, 2021

Trial Will Test AFM24-Tecentriq Combo for EGFR-positive Advanced Cancers

Immuno-Oncology News

Affimed will team up with Roche to conduct a Phase 1/2a clinical trial investigating its innate cell engager AFM24 — a form of immunotherapy — in combination with Tecentriq (atezolizumab) ... Read more

February 25, 2021February 25, 2021

VDR Gene Variations Increase Obesity Risk in Type 2 Diabetes, Study Finds

Genetic Obesity News

Certain variations in the DNA sequence of the vitamin D receptor (VDR) gene increase the risk for obesity in patients with type 2 diabetes, a South Korean study reports. The ... Read more

February 25, 2021February 26, 2021

Partnership Brings Quantitative Imaging Analysis to Diagnosis, Care

COPD News Today

A new collaboration is seeking to bring quantitative imaging analysis to diagnosis and care of patients with chronic lung diseases, including chronic obstructive pulmonary disease (COPD) and emphysema. The agreement ... Read more

February 25, 2021February 25, 2021

Parkinson’s UK Invests Up to £800,000 in New Trial Testing GDNF

Parkinson's News Today

Parkinson’s UK is paving the way for a future clinical trial that will continue to test a naturally occurring protein, the glial cell line-derived neurotrophic factor or GDNF, as a ... Read more