Many Fabry disease patients with heart involvement develop a slow and irregular heartbeat, called bradyarrhythmia, late in the disease course when heart damage is already advanced, according to a small study in Italy. The finding adds to previous studies reporting bradyarrhythmia as a late symptom of Fabry, discouraging its use as marker for the early identification of the disease, the researchers noted. Follow-up variations in QRS, a parameter of electrocardiogram (ECG), were strongly associated with…

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