HDAC6 Inhibitors Restore Neuromuscular Defects in Zebrafish

HDAC6 Inhibitors Restore Neuromuscular Defects in Zebrafish

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HDAC6 Inhibitors Restore Neuromuscular Defects in Zebrafish

Treatment with inhibitors of the HDAC6 protein, including the new compound CKD-504, was able to restore proper connections between nerves and muscles and improve movement in zebrafish with low levels of GARS — the gene implicated in Charcot-Marie-Tooth disease type 2D, a study found. The results suggest that HDAC6 blockade may be a promising therapeutic strategy for CMT2D and other diseases where nerve-muscle communication is impaired, the researchers suggested. The study, “Therapeutic Potential of CKD-504, a Novel…

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