Study Finds Potential Therapeutic Target in Piezo1 Ion Channel

Study Finds Potential Therapeutic Target in Piezo1 Ion Channel

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Study Finds Potential Therapeutic Target in Piezo1 Ion Channel

The levels of Piezo1, an ion channel that senses membrane tension in cells, was found to be increased in the lung blood vessels of patients with idiopathic pulmonary arterial hypertension (PAH) and in animal models of pulmonary hypertension (PH), a study says. Research showed that these higher levels trigger certain signaling pathways in pulmonary arterial endothelial cells (PAECs) which line lung blood vessels. This may stimulate the contraction and uncontrolled growth of pulmonary artery smooth…

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