Changes in Muscle Fibers and Energy Metabolism Evident in Types 3, 4

Changes in Muscle Fibers and Energy Metabolism Evident in Types 3, 4

316043

Changes in Muscle Fibers and Energy Metabolism Evident in Types 3, 4

The muscle atrophy and weakness characteristic of spinal muscular atrophy (SMA) is aggravated by the loss of fast-contracting white muscle fibers in patients with later-onset disease, an MRI study showed, reportedly for the first time. Production of the energy molecule ATP was also found to be impaired in white muscle fibers, which may explain why this particular fiber is vulnerable in SMA, leading the researchers to suggest ATP function as a biomarker or target for…

You must be logged in to read/download the full post.