Scientists Figure Out How Tezacaftor, Lumacaftor Interact With CFTR

Scientists Figure Out How Tezacaftor, Lumacaftor Interact With CFTR

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Scientists Figure Out How Tezacaftor, Lumacaftor Interact With CFTR

Researchers at The Rockefeller University in New York City have determined how two medications used to treat cystic fibrosis (CF), lumacaftor and tezacaftor, interact with the CFTR protein. The results suggest that these medicines bind to the protein — usually impaired or missing in people with CF — and help to keep it folded in its correct shape. “I am … hoping that these data will guide new therapy development to help people who do…

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