Parkinson’s-linked LRRK2 Mutations Impact Iron Balance in Brain Cells

Parkinson’s-linked LRRK2 Mutations Impact Iron Balance in Brain Cells

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Parkinson’s-linked LRRK2 Mutations Impact Iron Balance in Brain Cells

Parkinson’s-related mutations in the LRRK2 gene, in the presence of pro-inflammatory stimuli, affect the uptake and trafficking of iron in brain cells, leading to its abnormal accumulation and “mislocalization.” That’s according to a new study in mouse models and cells derived from Parkinson’s patients, which demonstrates “altered regulation of iron in Parkinson’s disease models based on the gene LRRK2,” Mark Cookson, PhD, the study’s senior author, of the National Institute on Aging, in Maryland, said…

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