Some Parkinson’s Medicines May Hurt Levodopa Effectiveness

Some Parkinson’s Medicines May Hurt Levodopa Effectiveness

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Some Parkinson’s Medicines May Hurt Levodopa Effectiveness

The use of several Parkinson’s disease medications was significantly associated with the increased abundance of a bacterial enzyme that converts levodopa to dopamine in the gut, potentially reducing levodopa’s availability in the brain, a study found. In Parkinson’s patients with rapidly progressing disease, the approved therapy Comtan (entacapone) enhanced enzyme abundance, suggesting this medicine may reduce the impact of levodopa. These findings support further research on the effect of Parkinson’s medications on gut microbial changes,…

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