Genetic Variant, Independent of Smoking, Is Risk Factor for COPD

Genetic Variant, Independent of Smoking, Is Risk Factor for COPD

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Genetic Variant, Independent of Smoking, Is Risk Factor for COPD

A single alteration in the sequence of the CHRNA5 gene that leads to inflammation, tissue remodeling, and abnormal repair of airway cells was found, in a recent study, to be a risk factor for chronic obstructive pulmonary disease (COPD). Notably, this gene variant is involved in nicotine-responding/dependent pathways, but was found to not be linked with smoking, the study shows. The changes caused by the gene alteration, observed in mouse models and human nasal samples, were…

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