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Case Study: Secondary CAD Caused by Rare Cancer in Spleen

A case of secondary cold agglutinin disease (CAD) was triggered by a rare, undetected slow-growing type of immune cell cancer in the spleen. The case study, “Cold agglutinin syndrome secondary to splenic marginal zone lymphoma: a case report,” was published in the journal Hematology, Transfusion and Cell Therapy. In CAD, antibodies known as cold agglutinins bind red blood cells in cold temperatures, which activates the immune system to target and destroy these cells (a process…