Fatty Molecules in Cells May Play Role in Parkinson’s Development

Fatty Molecules in Cells May Play Role in Parkinson’s Development

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Fatty Molecules in Cells May Play Role in Parkinson’s Development

Having longer-than-normal fatty molecules and an inactive enzyme called cathepsin-B in nerve cells’ recycling centers may increase the risk of developing Parkinson’s disease in people with mutations in the GBA1 gene, the disease’s most common genetic risk factor. This is the hypothesis generated by a recent study, titled “Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo,” published in the journal Proceedings of the National Academy of Sciences, which showed…

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