Potential Oral Treatment Reverses Advanced PAH in Rats, Study Shows

Potential Oral Treatment Reverses Advanced PAH in Rats, Study Shows

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Potential Oral Treatment Reverses Advanced PAH in Rats, Study Shows

An orally available small molecule, BI113823, successfully reversed the progression of severe, advanced pulmonary arterial hypertension (PAH) in a rat model, a study demonstrated. The experimental medicine lowered pulmonary blood pressure, reduced blood vessel thickening, suppressed inflammatory responses, and prevented right heart failure and death. These findings support the further development of this therapy in people with established PAH, the scientists noted. The study, “Reversal of pulmonary arterial hypertension and neointimal formation by kinin B1…

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