Novel Approach Holds Potential to Target Type B Neurological Defects

Novel Approach Holds Potential to Target Type B Neurological Defects

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Novel Approach Holds Potential to Target Type B Neurological Defects

Scientists have discovered a potential novel approach to possibly correct the neurological features of Sanfilippo syndrome type B and other forms of the disease characterized by the accumulation of heparan sulfate and progressive neurodegeneration. Using a cellular model of Sanfilippo type B, the researchers found that clearing excess levels of heparan sulfate (HS) outside nerve cells reduced lysosomal defects and HS toxic buildup inside cells, restoring their ability to grow and mature. HS clearance outside…

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