Elevated Beta-amyloid Levels Seen in Patients With Freezing of Gait

Elevated Beta-amyloid Levels Seen in Patients With Freezing of Gait

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Elevated Beta-amyloid Levels Seen in Patients With Freezing of Gait

People with advanced Parkinson’s disease and freezing of gait (FOG) have higher levels of beta-amyloid — a protein that forms toxic clumps in the brains of those with Alzheimer’s disease — in their cerebrospinal fluid relative to patients without FOG, a small study reported. The presence of FOG was also associated with significantly lower levels of fractalkine, an anti-inflammatory molecule, in the cerebrospinal fluid (CSF, the liquid that surrounds the brain and spinal cord). Larger, longitudinal studies are needed to…

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