Combined Gene Therapy Shows Promise, but Not Synergy, in Mice

Combined Gene Therapy Shows Promise, but Not Synergy, in Mice

313130

Combined Gene Therapy Shows Promise, but Not Synergy, in Mice

A combined gene therapy that delivered two nerve growth factors — NRG1-I and NRG1-III — to muscle and nerve cells improved motor function and delayed disease onset in a mouse model of amyotrophic lateral sclerosis (ALS), a study demonstrated. However, the combo therapy did not show a synergistic effect, as hoped, compared with treatment with NRG1-I and NRG1-III alone, “suggesting an overlap between NRG1-I and NRG1-III activated pathways and their beneficial effects,” the researchers noted.…

You must be logged in to read/download the full post.