Chemical Modification Key for MeCP2 Protein to Support Nerve Cells

Chemical Modification Key for MeCP2 Protein to Support Nerve Cells

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Chemical Modification Key for MeCP2 Protein to Support Nerve Cells

A specific mutation of MECP2 — the main disease-causing gene of Rett syndrome — prevents a type of chemical modification on the resulting MeCP2 protein that is key for nerve cell growth, maturation, and function, a study in lab-grown cells and mice shows. In addition, these defects were associated with an impaired regulation of brain-derived neurotrophic factor (BDNF), a known gene target of MeCP2 that is crucial for brain development. These findings highlight the importance of…

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