The loss of chemical modifications in the regulatory sequence of the TARDBP gene, called DNA methylation, seems to contribute to increased levels and clumping of the TDP-43 protein in the motor cortex of people with amyotrophic lateral sclerosis (ALS), a study found. As methylation in this gene — which prevents cellular machinery from reading this gene and making proteins from it — decreases with age, the study’s findings begin to explain why older age is…

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