Age-related Loss in Cell’s Control Over Protein Levels Tied to Clumping

Age-related Loss in Cell’s Control Over Protein Levels Tied to Clumping

312930

Age-related Loss in Cell’s Control Over Protein Levels Tied to Clumping

The loss of chemical modifications in the regulatory sequence of the TARDBP gene, called DNA methylation, seems to contribute to increased levels and clumping of the TDP-43 protein in the motor cortex of people with amyotrophic lateral sclerosis (ALS), a study found. As methylation in this gene — which prevents cellular machinery from reading this gene and making proteins from it — decreases with age, the study’s findings begin to explain why older age is…

You must be logged in to read/download the full post.