Study Sheds Light on Effects of USP8 Mutations on Disease Development

Study Sheds Light on Effects of USP8 Mutations on Disease Development

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Study Sheds Light on Effects of USP8 Mutations on Disease Development

Scientists have decoded molecular processes of a gene whose defects are implicated in Cushing’s disease and some cancers. Their study found that mutations in the ubiquitin-specific protease 8 (USP8) gene prevent a self-suppressing mechanism of the resulting enzyme, leading to its overactivation. Overactivation of this enzyme has been shown to cause abnormal cell growth in cancer tumors with USP8 mutations. The new findings provide further insights on the molecular mechanisms behind that overactivation, which can…

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