Antioxidants Help ERT Efficacy in Pompe, Early Study Suggests

Antioxidants Help ERT Efficacy in Pompe, Early Study Suggests

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Antioxidants Help ERT Efficacy in Pompe, Early Study Suggests

Antioxidants can increase the effectiveness of enzyme replacement therapy (ERT) for Pompe disease caused by oxidative stress, the damage in cells or tissues by reactive oxygen molecules, according to a study in cells and mice. The findings also showed that enhancing autophagy — the destruction of damaged or redundant components within cells — reduces oxidative stress and increases ERT efficacy. The study, “Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease,” was published in…

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