Targeted Gene Therapy Boosts Levodopa’s Benefits in Mouse Study

Targeted Gene Therapy Boosts Levodopa’s Benefits in Mouse Study

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Targeted Gene Therapy Boosts Levodopa’s Benefits in Mouse Study

A gene therapy targeting the substantia nigra, the brain region with dopamine-producing nerve cells, may boost the benefits of levodopa for people with Parkinson’s disease, a study reports. This idea was tested in a new mouse disease model — one in which Parkinson’s symptoms appeared after disrupting a protein complex in mitochondria, organelles involved in the production of energy in cells (the cell’s powerplants). The gene therapy appeared to restore healthy movement to these mice. And the…

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