Continuous BDNF Supply by Stem Cells May Have Therapeutic Potential

Continuous BDNF Supply by Stem Cells May Have Therapeutic Potential

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Continuous BDNF Supply by Stem Cells May Have Therapeutic Potential

Stem cells engineered to produce a constant level of a downstream target of the MECP2 protein, called brain-derived neurotrophic factor (BDNF), increased the development of new neurons and prevented body weight loss in a mouse model of Rett syndrome. The study with that finding, “Brain-Derived Neurotrophic Factor Secreting Human Mesenchymal Stem Cells Improve Outcomes in Rett Syndrome Mouse Models,” was published in the journal Frontiers in Neuroscience. Rett syndrome is caused mostly by a deficiency in…

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