MECP2 Deficiency Linked to Low Acetylcholine, Increased Symptoms

MECP2 Deficiency Linked to Low Acetylcholine, Increased Symptoms

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MECP2 Deficiency Linked to Low Acetylcholine, Increased Symptoms

Female rats genetically engineered to carry a deficient Mecp2 gene — whose mutations are the leading cause of Rett syndrome — show social, behavioral, and motor symptoms that are similar to those of humans with the neurodevelopmental disorder, a study reports. These symptoms were associated with low levels of the chemical messenger acetylcholine in the brain. According to the scientists, this new animal model could be useful in studying the mechanisms underlining Rett syndrome — and for developing new…

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