Upper Limb Strength, Function Worsen Over Time in DMD

Upper Limb Strength, Function Worsen Over Time in DMD

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Upper Limb Strength, Function Worsen Over Time in DMD

Upper limb strength, function, and muscle fat fraction continuously worsen over time in Duchenne muscular dystrophy (DMD) patients with mutations amenable to exon 53 skipping, according to three-year data from a natural history study. Notably, this progression of upper limb involvement was assessed reliably with strength, function, and muscle MRI measures in patients who could still walk (ambulatory) and those who had lost such ability (non-ambulatory), supporting their use as outcomes in DMD clinical trials. In addition,…

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