Antioxidant NAC Found to Ease Lung Scarring in Preclinical Study

Antioxidant NAC Found to Ease Lung Scarring in Preclinical Study

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Antioxidant NAC Found to Ease Lung Scarring in Preclinical Study

Treatment with the antioxidant N-acetylcysteine (NAC) lowered blood levels of pro-inflammatory molecules and reduced lung scarring, or fibrosis, in a rat model of chronic obstructive pulmonary disease (COPD), a study shows. This beneficial effect was associated with the suppression of two molecules — von Willebrand factor (VWF) and p38 mitogen-activated protein kinase (MAPK) — which promoted the restoration of immune responses and the repression of epithelial-mesenchymal transition (EMT). EMT is a key process in fibrosis by…

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