ZNF483 Protein Likely Affects Gene Activity in Nerve Cells in Rett

ZNF483 Protein Likely Affects Gene Activity in Nerve Cells in Rett

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ZNF483 Protein Likely Affects Gene Activity in Nerve Cells in Rett

Binding to the zinc finger protein 483 (ZNF483) may move the MeCP2 protein — defective in most cases of Rett syndrome — away from the cell nucleus, which likely affects gene activity in nerve cells, a lab study suggests. These findings shed light on the potential processes regulating the function and localization of the MeCP2 protein in people with Rett syndrome. The researchers said their work “characterized the relationship between ZNF483 and MeCP2 at the…

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