Liver Disease in CF Appears Linked to Problems in CFTR Protein

Liver Disease in CF Appears Linked to Problems in CFTR Protein

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Liver Disease in CF Appears Linked to Problems in CFTR Protein

A unique interaction between CFTR — the protein defective in people with cystic fibrosis (CF) — and two pro-inflammatory proteins may explain why some CF patients develop liver disease, researchers reported. Their work suggests that the CFTR protein can act as an anchor, bringing certain proteins — including the pro-inflammatory beta-catenin and the p65 subunit of NF kappa B — together to prevent their activation. When CFTR is missing or dysfunctional, these proteins are activated, which…

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