Blocking Specific PI3K Protein Prevents PH in Animal Models

Blocking Specific PI3K Protein Prevents PH in Animal Models

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Blocking Specific PI3K Protein Prevents PH in Animal Models

Targeting a protein called p110a, a part of the PI3K family of enzymes, may be useful for preventing or even reversing pulmonary hypertension, research done in cells and rodent models showed. “Targeted inhibition of [p110a] offers a disease-modifying treatment approach, which is readily accessible by small molecule inhibitors and warrants further evaluation in clinical trials,” the researchers wrote. Results of the study “Disrupted PI3K subunit p110α signaling protects against pulmonary hypertension and reverses established disease in…

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