DSP Gene Variant May Aid Survival in IPF, Guide Esbriet or Ofev Use

DSP Gene Variant May Aid Survival in IPF, Guide Esbriet or Ofev Use

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DSP Gene Variant May Aid Survival in IPF, Guide Esbriet or Ofev Use

Certain genetic variants appear to lead to better survival in people with idiopathic pulmonary fibrosis (IPF) who are on anti-fibrotics, suggesting that genetic testing may help to select patients for specific treatments, a real-world study found. Specifically, people carrying a variant of the DSP gene, known as the rs2076295 (G) allele, may benefit most from treatment with Ofev (nintedanib). In turn, those carrying two variants of the rs2076295 (T) allele (TT genotype), may benefit most…

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