Study Explores Imbalances in Brain That Lead to LID

Study Explores Imbalances in Brain That Lead to LID

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Study Explores Imbalances in Brain That Lead to LID

An imbalance between the signaling molecules dopamine and sonic hedgehog in the brain may be the cause of the movement disorder caused by dopamine-replacing medicines used to treat Parkinson’s disease. That’s according to findings published in Communications Biology, in the study, “Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia.” Parkinson’s disease is caused by the death and dysfunction of dopaminergic neurons — nerve cells that make a…

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