Lung Development Molecule Sox9 May Be Potential Target for IPF

Lung Development Molecule Sox9 May Be Potential Target for IPF

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Lung Development Molecule Sox9 May Be Potential Target for IPF

The levels of Sox9 — a molecule that promotes lung scarring, or fibrosis — are significantly higher in the lungs of both patients and mouse models of idiopathic pulmonary fibrosis (IPF) than in those of their healthy counterparts, a study shows. Excessive Sox9 levels were found to promote fibroblasts’ maturation into myofibroblasts, migration, and production of scarring-related molecules — all key contributing events for pulmonary fibrosis (PF). Notably, blocking Sox9’s activity reduced fibroblast maturation and lung fibrosis…

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