Blood NfL Levels May Mark SMA Severity, Therapy Efficacy in Very Young

Blood NfL Levels May Mark SMA Severity, Therapy Efficacy in Very Young

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Blood NfL Levels May Mark SMA Severity, Therapy Efficacy in Very Young

Blood levels of neurofilament light chain (NfL) — a marker of nerve cell damage — in children and adolescents with spinal muscular atrophy (SMA) are significantly higher than those of age-matched healthy peers and associate with disease severity, a study found. NfL blood levels also reliably reflect levels in the cerebrospinal fluid (CSF), and show a potential to serve as a treatment response biomarker in infants with SMA type 1, and in toddlers with milder…

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