SFPQ Protein Helps to Restore CFTR in Cells With Common Mutation

SFPQ Protein Helps to Restore CFTR in Cells With Common Mutation

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SFPQ Protein Helps to Restore CFTR in Cells With Common Mutation

Increasing the levels of the SFPQ protein helped to restore expression and function of the CFTR protein in cells with a F508del mutation in the CFTR gene, the most common cause of cystic fibrosis (CF). Work also showed that SFPQ levels were unusually low in these cells, suggesting this protein “may play a role in CF lung disease,” its researchers wrote. The study, “SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells, was published in the…

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