Molecule Allowing for Macrophages to Die as Intended Might Treat IPF

Molecule Allowing for Macrophages to Die as Intended Might Treat IPF

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Molecule Allowing for Macrophages to Die as Intended Might Treat IPF

Blocking the activity of a cell death-suppressing protein called Bcl-2 promoted the death of macrophages — a type of immune cell involved in pulmonary fibrosis (PF) — and reversed established lung scarring in a mouse model, a study showed. Notably, Bcl-2’s anchoring at the surface of macrophage mitochondria was found to be behind the cells’ previously reported resistance to programed cell death (apoptosis) in PF. (Mitochondria are small organelles inside cells involved in energy production…

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