3D Brain Organoids Capture Hallmarks ‘Only Seen in Patients’

3D Brain Organoids Capture Hallmarks ‘Only Seen in Patients’

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3D Brain Organoids Capture Hallmarks ‘Only Seen in Patients’

Researchers developed “mini-brains” — midbrain-like organoids — that recapitulate for a first time two key Parkinson’s hallmarks in that organ: the formation of toxic protein clumps known as Lewy bodies and the loss of dopamine-producing neurons. A combination of two known Parkinson’s risk factors — a deficiency of the beta-glucocerebrosidase (GCase) enzyme and overproduction of the alpha-synuclein protein, the main component of Lewy bodies — is also part of these organoids. “These experiments are the first…

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