Subtle Changes in MicroRNA-218 May Fuel ALS

Subtle Changes in MicroRNA-218 May Fuel ALS

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Subtle Changes in MicroRNA-218 May Fuel ALS

Dropping the levels of microRNA-218 (miR-218) — a small molecule that regulates the activity of other genes — below a certain threshold leads to severe motor neuron damage, paralysis, and death in a mouse model of amyotrophic lateral sclerosis (ALS), a study shows. The findings, combined with the fact that ALS patients usually show lower-than-normal miR-218 levels, highlight how subtle changes in this particular microRNA, instead of an all-or-nothing model, may contribute to ALS. Gene activity…

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