Masitinib Helps Keep Inflammatory Mast Cells From Spinal Cord

Masitinib Helps Keep Inflammatory Mast Cells From Spinal Cord

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Masitinib Helps Keep Inflammatory Mast Cells From Spinal Cord

Mast cells, a type of immune cell, infiltrate the spinal cord of amyotrophic lateral sclerosis (ALS) patients and rodent models of the disease, exhibiting pro-inflammatory features that are likely involved in motor neuron and microvasculature damage, a study suggests. Notably, treating these mice models with masitinib — an experimental oral therapy by AB Science that showed promise as an add-on treatment in a clinical trial in ALS patients — lowered the number of mast cells in the spinal cord…

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