Low Oxygen Increases Chloride Levels in PASMCs in Animal Study

Low Oxygen Increases Chloride Levels in PASMCs in Animal Study

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Low Oxygen Increases Chloride Levels in PASMCs in Animal Study

Higher levels of chloride in pulmonary artery smooth muscle cells (PASMCs) may contribute to the development of pulmonary hypertension (PH) after exposure to low oxygen (hypoxia), a study in a rat model suggested. The study, “Increased intracellular Cl− concentration in pulmonary arterial myocytes is associated with chronic hypoxic pulmonary hypertension,” was published in the American Journal of Physiology-Cell Physiology. Experiencing reduced oxygen levels for a lengthy period is known to cause changes to the structure…

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