Way of Detecting PMP22 Gene Activity May Advance CMT1A Therapies

Way of Detecting PMP22 Gene Activity May Advance CMT1A Therapies

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Way of Detecting PMP22 Gene Activity May Advance CMT1A Therapies

A new way to rapidly identify compounds with the ability of lower production of PMP22, a protein that is overproduced in Charcot-Marie-Tooth disease type 1A (CMT1A), has been developed, and could be helpful in spotting molecules with a potential to treat this disease. The approach takes advantage of gene editing and light-emitting technology to detect a specific process, known as transcription, by which a gene’s DNA sequence is converted into messenger RNA (mRNA), which serves…

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