‘Pulmonary Insults’ of Sanfilippo Type A May Be Due to Lung Lubricant

‘Pulmonary Insults’ of Sanfilippo Type A May Be Due to Lung Lubricant

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‘Pulmonary Insults’ of Sanfilippo Type A May Be Due to Lung Lubricant

Properties of a lubricant of the small air sacs (alveoli) that is essential for normal lung function appear to be altered in Sanfilippo syndrome type A, a study in mice reported. Changes in the mechanism and activity of this lung lubricant, known as pulmonary surfactant, “may explain the increased susceptibility of MPS IIIA [Sanfilippo type A] patients to respiratory infections and other pulmonary insults,” its researchers wrote, beyond this disease’s “devastating consequences in the brain.” The study,…

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