2 Compounds Targeting Oxidative Stress Prevent CMT Symptoms in Mice

2 Compounds Targeting Oxidative Stress Prevent CMT Symptoms in Mice

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2 Compounds Targeting Oxidative Stress Prevent CMT Symptoms in Mice

Two approved compounds, the antibiotic florfenicol or the MitoQ antioxidant supplement, prevented symptom development in a mouse model of Charcot-Marie-Tooth disease (CMT) caused by mutations in the GDAP1 gene, a study shows. Notably, these benefits were associated with a reduction in oxidative stress, an imbalance between the production of potentially harmful reactive oxygen species (ROS) and a cell’s ability to detoxify them with antioxidants, causing cell and tissue damage. Study findings highlight oxidative stress as…

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