Study Explores Common, Targetable Hallmark of CMT2 Subtypes

Study Explores Common, Targetable Hallmark of CMT2 Subtypes

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Study Explores Common, Targetable Hallmark of CMT2 Subtypes

Abnormalities in cellular transport and in mitochondria (the cell’s powerhouses) are a common feature of motor neurons derived from people with four different subtypes of Charcot-Marie-Tooth disease type 2 (CMT2), a study shows. Notably, treatment with a suppressor of DLK — a molecule involved in mitochondrial damage and transport inside nerve cells — partially rescued mitochondrial deficits in the two most-affected subtypes. These findings shed light on the common underlying mechanisms of CMT2 subtypes and…

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