Excess Alpha-synuclein Directly Linked to Mitochondrial Problems

Excess Alpha-synuclein Directly Linked to Mitochondrial Problems

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Excess Alpha-synuclein Directly Linked to Mitochondrial Problems

Higher-than-normal levels of alpha-synuclein — the protein that accumulates in toxic clumps in Parkinson’s disease — affect the shape, dynamics, and health of mitochondria, which are the powerhouses of the body’s cells, according to a study in a fruit fly model. “When fruit fly larvae expressed alpha-synuclein at elevated levels similar to what is seen in Parkinson’s disease, many of the mitochondria we observed became unhealthy, and many became fragmented,” Shermali Gunawardena, PhD, the study’s…

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