Rett Protein’s Loss Tied to Premature Closing of Brain Plasticity Window

Rett Protein’s Loss Tied to Premature Closing of Brain Plasticity Window

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Rett Protein’s Loss Tied to Premature Closing of Brain Plasticity Window

The lack of a working MeCP2 protein — the most common cause of Rett syndrome — prematurely closes a window of neuronal plasticity in a brain region involved in social memory, a study showed. Neuronal plasticity is the brain’s ability to re-wire itself, to strengthen or weaken its neuronal connections, in response to stimuli. Notably, this early shutdown was associated with the formation of perineuronal nets (PNNs) — net-like structures around nerve cells that regulate their plasticity —…

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