Metformin, for Diabetics, Effectively Treats Models of Silica-induced PF

Metformin, for Diabetics, Effectively Treats Models of Silica-induced PF

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Metformin, for Diabetics, Effectively Treats Models of Silica-induced PF

A type 2 diabetes medication, metformin significantly eased lung inflammation and scarring (fibrosis) in a mouse model of silica-induced pulmonary fibrosis (PF), both at early and late stages of the disease. Notably, these benefits were found to be associated with a reduction in oxidative stress, inflammation, fibrotic markers, and maturation of lung fibroblast cells into myofibroblasts — the main drivers of PF. (Oxidative stress is an imbalance in the production of reactive oxygen species, harmful molecules that…

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